H3041
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H3041
Sigma
Halopemide 
≥98% (HPLC)
| Synonym: | N-(2-(4-(5-Chloro-2-oxo-1-benzimidazolinyl)piperidino)ethyl)-p-fluorobenzamide |
| CAS Number: | 59831-65-1 |
| Linear Formula: | C21H22ClFN4O2 |
| Molecular Weight: | 416.88 |
| MDL number: | MFCD00866684 |
Description
| Biochem/physiol Actions | Halopemide is a dopamine receptor antagonist and a phospholipase D2 inhibitor. Halopemide may be used as a screen to identify inhibitors of human PLD2 using an in vitro biochemical assay. |
Properties
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
Safety
References
| reference | Monovich, L., et al, Optimization of Halopemide for Phospholipase D2 inhibition. Bioorg. Med. Chem. Lett. 17, 2310-2311, (2007) |
| Scott, SA., et al, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chem. Biol. 2, 108-117, (2009) | |
| Wenjuan, Su., et al, FIPI, a Phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol. Pharmacol. 2008, 1, (2008) |
